《英文msh詞典》Receptor,Activin
[入口詞] Receptor,Activin
[主題詞] Activin Receptors
[英文釋義] Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES,thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS,TRANSFORMING GROWTH FACTOR BETA),ALK's consist of two different but related protein kinases,Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS,TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS,TYPE I ) with subsequent activation of the type I kinase activity.