Sedoval

《英文msh詞典》Sedoval
[入口詞] Sedoval
[主題詞] Thalidomide
[藥動學] Teratogens
[英文釋義] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic,but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes,and modulates other cytokine action.