《英文msh詞典》Switching,Class
[入口詞] Switching,Class
[主題詞] Immunoglobulin Class Switching
[英文釋義] Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.