Syndrome,Hutchinson-Gilford

《英文msh詞典》Syndrome,Hutchinson-Gilford
[入口詞] Syndrome,Hutchinson-Gilford
[主題詞] Progeria
[英文釋義] An abnormal congenital condition,associated with defects in the LAMIN TYPE A gene,which is characterized by premature aging in children,where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors,especially SARCOMA.