ddNus
《英文msh詞典》ddNus
[入口詞] ddNus
[主題詞] Dideoxynucleosides
[藥動學] Reverse Transcriptase Inhibitors
[英文釋義] Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.