11beta-HSD2
《英文msh詞典》11beta-HSD2
[入口詞] 11beta-HSD2
[主題詞] 11-beta-Hydroxysteroid Dehydrogenase Type 2
[英文釋義] An high-affinity,NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts undirectionally to catalyze the dehdrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed,APPARENT MINERALOCORTICOID EXCESS SYNDROME.