2',3'-Dideoxycytidine

《英文msh詞典》2',3'-Dideoxycytidine
[同義詞] 2',3'-Dideoxycytidine
[主題詞] Zalcitabine
[藥動學] Reverse Transcriptase Inhibitors
[中文釋義] 2',3'-雙去氧胞苷
[英文釋義] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations,acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.