《英文msh詞典》Activation,Insertional
[入口詞] Activation,Insertional
[主題詞] Mutagenesis,Insertional
[英文釋義] Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements,or cause unregulated expression of the proto-oncogene resulting in tumor formation.