Biocisplatinum
《英文msh詞典》Biocisplatinum
[入口詞] Biocisplatinum
[主題詞] Cisplatin
[藥動學] Radiation-Sensitizing Agents
[英文釋義] An inorganic and water-soluble platinum complex. After undergoing hydrolysis,it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.