《英文msh詞典》Domain,HMG-1-Box
[入口詞] Domain,HMG-1-Box
[主題詞] HMG-Box Domains
[英文釋義] DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS,a number of sequence specific TRANSCRIPTION FACTORS,and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription,recombination,or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)