《英文MSH詞典》NSC-606170
[入口詞] NSC-606170
[主題詞] Zalcitabine
[藥動(dòng)學(xué)] Reverse Transcriptase Inhibitors
[英文釋義] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations,acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.