Steroids,Cardiotonic

《英文msh詞典》Steroids,Cardiotonic
[入口詞] Steroids,Cardiotonic
[主題詞] Cardiac Glycosides
[藥動學] Enzyme Inhibitors
[英文釋義] Substances obtained from species of Digitalis,Strophanthus,and other plants that contain specific steroid glycosides or their semisynthetic derivatives and used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters,but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the Na(+)-K(+)-exchanging ATPase and they are often used in cell biological studies for that purpose.