Sulfoximine,Buthionine
《英文msh詞典》Sulfoximine,Buthionine
[入口詞] Sulfoximine,Buthionine
[主題詞] Buthionine Sulfoximine
[藥動學] Radiation-Sensitizing Agents
[英文釋義] A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)