Motif,HTH

《英文msh詞典》Motif,HTH
[入口詞] Motif,HTH
[主題詞] Helix-Turn-Helix Motifs
[英文釋義] The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids,which constitute the turn. The two helices are held at a fixed angle,primarily through interactions between the two helices. (From Alberts et al.,Molecular Biology of the Cell,3d ed,p408-9)