Syndrome,Kallmann

《英文msh詞典》Syndrome,Kallmann
[入口詞] Syndrome,Kallmann
[主題詞] Kallmann Syndrome
[英文釋義] Congenital and familial disorder characterized by hypogonadotropic hypogonadism,eunuchoidal features,and anosmia or hyposmia. It is caused by a defect in the synthesis and/or release of LHRH (luteinizing hormone-releasing hormone; GONADORELIN) from the hypothalamus as a result of faulty embryonic neuronal migration. The gene responsible for this is found in the region Xp22.3 on the short arm of the X chromosome. There is a homolog on the Y chromosome. The syndrome is more prevalent in males by a ratio of three to one.