alphaIIbbeta3,Integrin
《英文msh詞典》alphaIIbbeta3,Integrin
[入口詞] alphaIIbbeta3,Integrin
[主題詞] Platelet Glycoprotein GPIIb-IIIa Complex
[英文釋義] Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such,it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.