histone
美 ['h?sto?n] 
英 ['h?st??n]
- n.【生化】組蛋白
- 網絡組織蛋白；抗組蛋白抗體；H組蛋白
詞形變化
復數：histones
英漢解釋
英英解釋
例句
In contrast to the universal nature of the DNA code, the histone language and its decoding machinery differ among animals, plants and fungi.
與此相反的普遍性的DNA代碼，組的語言和其解碼機制不同的動物，植物和真菌。
Genes can also be silenced by modification of the histone proteins that make up the "smart stuffing" in chromosomes.
基因也可以通過組蛋白的修飾被沉默，組蛋白是組裝染色體的“填料”。
These patterns are referred to as 'the histone code'.
這些機制被稱為“組蛋白密碼”。
Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome.
最近的研究跨釀酒酵母基因組比對了組蛋白修飾。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
靶向DNA甲基化和組蛋白去乙酰化酶的幾個表觀藥物已經在臨床試驗中被測試。
When methyl groups are added to a histone, they modify its properties and alter the frequency at which a particular gene is expressed.
當甲基加到組蛋白后，這些基團會修飾它的性質并改變它上面特定基因的表達頻率。
The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.
組蛋白變體的合并最可能具有表觀影響，并有助于染色體的結構化改變。
Dr. Fischer's research shows that when young mice are learning, an acetyl group binds to a particular point on the histone protein.
費舍爾博士的研究顯示，當一只年輕的白鼠在學習時，一個乙酰基群在組蛋白上抱成特殊的節點。
A small molecule called an acetyl group attaches to a particular histone known as H4.
一個小小的分子稱作一個乙酰基團，它黏在一個稱作H4的特殊組蛋白上。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
組蛋白賴氨酸甲基化是組蛋白尾段發生的一種重要共價修飾，在基因的表觀遺傳轉錄調控中起著關鍵的作用。
DNA wraps around histone spools to form a rosarylike chain, which is then twisted into a bundle[ see illustration on opposite page].
DNA纏繞在組織蛋白構成的線軸上，形成類似念珠的鏈子，然后再繞成一束（見上頁〈因音量的控制〉。
RSEG is also able to incorporate a control sample and find genomic regions with differential histone modifications between two samples.
RSEG也能夠包含一個對照樣本，并找到兩個樣本間具有差異組蛋白修飾的基因組區域。
These alterations in the histone code may alter gene expression pattern to set the stage for leukemogenesis.
組蛋白密碼的這些改變可能改變基因表達模式以設定白血病發生狀態。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
活化的差異組蛋白修飾標記物對抑制基因的改變伴隨著這些DNA甲基化改變。
Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development.
這兩個DNA甲基化和組蛋白修飾參與建立模式的發育過程中基因的鎮壓。
Background: Histone acetylation as an epigenetic change is widely studied in cancer.
目的：組蛋白乙酰化作為一種后生變化在腫瘤領域被廣泛研究。
The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity.
本發明提供了用于抑制組蛋白脫乙酰基酶酶活性的化合物和方法。
The hypothesis of "Histone code" suggests an existing way of program information of eukaryotic gene control.
“組蛋白編碼”假說提示了真核生物基因調控的程序性信息的存在方式。
Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein.
組蛋白標記經由一個染色質結合蛋白質，通過影響剪接調控子的招募而影響剪接結果。
Objective: To improve the synthetic procedure of the histone deacetylase (HDAC) inhibitor SAHA.
目的：改進組蛋白去乙酰化酶抑制劑SAHA的合成工藝。
Covalent modifications of histone tails play a key role in the regulation of chromatin structure and control of transcriptional activity.
染色體組蛋白的共價修飾在調節染色體結構，控制基因的轉錄等方面發揮重要的作用。
As in the Alzheimer's mice, drugs that boosted histone acetylation improved the older mice's performance on tests of rodent cognition.
如同阿爾茨海默病鼠，增強組蛋白乙酰化的藥物改善了年老小鼠在認知測試中的表現。
The canonical histone proteins are encoded by replication-dependent genes and must rapidly reach high levels of expression during S phase.
規范組蛋白編碼的復制依賴基因和必須迅速達到高水平的表達在S期。
Some portions of the double stranded DNA were opened. The binding of histone to DNA was observed with molecular combing.
直接觀察到了單個DNA分子在拉伸力作用下的熔化現象，局部雙鏈被打開。
Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified.
表現在啟動子、絕緣子、增強子和轉錄區域的組蛋白甲基化的典型模式被確定。
Chromosome banding patterns are correlated with unique patterns of histone modifications.
染色體帶型和組蛋白修飾的特有模式相關。
DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling.
DNA甲基化在基因轉錄過程中扮有重要角色，并與組蛋白修飾、染色質構型重塑共同參與轉錄調控。
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
認識到開發新穎治療劑的要求，本發明提供新穎組蛋白去乙酰化酶抑制劑。
histone status renders DNA sequences accessible or inaccessible for transcription.
轉錄過程中，組蛋白的狀態能夠影響DNA序列相互靠近或者遠離。
This review mainly focuses on recent advances in histone methylation effector protein's function mechanism.
文章從組蛋白甲基化效應分子的作用機制方面綜述了這一領域的研究進展。
Covalent modifications to histone proteins play a critical role in regulating gene transcription.
組蛋白的共價修飾在調控基因轉錄中起著關鍵性的作用。
Effective inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation.
有效的PKC催化組蛋白磷酸化抑制劑。
The 146 bp of DNA wrapped twice around the core histone octamer are clearly visualized.
146個堿基的DNA包裹兩次圍繞核心組八顯然可視化。
Histone lysine methylation plays a key role in the organization of chromatin structure and the regulation of gene expression.
組蛋白賴氨酸甲基化中起著關鍵作用的組織染色質結構和基因表達調控。
The author introduced current knowledge of the mechanisms of histone H2B ubiquitination and its significance.
筆者介紹了組蛋白H2B的泛素化機制及其意義。
In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypo-acetylation.
此外，活動的非組蛋白可以調節通過HDAC介低乙酰化。
In the histone code the methylation target is known as H3K9, where K stands for lysine.
這一組蛋白的甲基化靶點就稱為H3K9，其中K代表賴氨酸。
The level of histone acetylation plays an important role in progression, proliferation and differentiation of leukemia.
組蛋白乙酰化水平的異常在白血病的發展、增殖和分化中起著很重要的作用。
To reverse the memory loss, doctors inject a compound called a histone deacetylase inhibitor.
為了逆轉記憶遺失，醫生在復合物中添加了組蛋白脫乙酰基酶抑制物。
Histone proteins both protect DNA and regulate genes as they combine with DNA to form chromatin.
組蛋白既保護DNA也在它們與DNA結合形成染色質時調節基因表達。
