Acid,Mycophenolic
《英文msh詞典》Acid,Mycophenolic
[入口詞] Acid,Mycophenolic
[主題詞] Mycophenolic Acid
[藥動學] Enzyme Inhibitors
[英文釋義] An antibiotic substance derived from Penicillium stoloniferum,and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells,lymphocytes,and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al.,Goodman and Gilman's The Pharmacological Basis of Therapeutics,9th ed,p1301)