變?yōu)?/c>一種新的朊蛋白,這種新的朊蛋白能感染健康的倉(cāng)鼠和老鼠。
The cause of FSE is an infectious agent called a prion, and prion protein accumulates in the brain tissue as a substance called amyloid.
FSE的病原是一種感染性蛋白,這種感染性蛋白像淀粉質(zhì)一樣在腦組織積累。
However, prion diseases are considered to be representative of other protein precipitation-associated diseases .
然而,阮病毒疾病被認(rèn)為是其他蛋白相關(guān)疾病的典型。
The origin of the crisis was the feeding of cattle with animal feed that was contaminated by a new pathogenic agent - a prion.
這場(chǎng)危機(jī)起源于使用動(dòng)物飼料喂養(yǎng)牛,這些動(dòng)物飼料都被一種新的致病體—朊蛋白污染了。
There's hope that by disentangling PrP's normal job, prion diseases will become easier to understand.
PrP及朊病毒疾病的的常規(guī)研究將有可能變得更加容易理解。
In 2003, Mead and his colleagues discovered a much more common variant of the prion gene that provides protection against prion diseases.
2003年,米德和他的同事發(fā)現(xiàn)了朊病毒基因更普遍的變體,可以抗御與朊病毒有關(guān)的疾病。
Prion diseases affect the brains of a number of mammals, including humans.
朊病毒疾病能影響許多哺乳動(dòng)物的大腦(包括人類)。
However, the prion protein in scrapie-infected brain tissue differs from normal prion protein in some of its properties.
然而,在感染羊瘙癢病的大腦組織的普利昂蛋白在某些性質(zhì)上不同于一般的普利昂蛋白。
The prion-like folding behavior of a multimer, consisted of 27 individual model proteins, is studied with simple lattice model.
我們利用簡(jiǎn)單的格點(diǎn)模型來(lái)研究由27個(gè)單體蛋白聚集成的多聚體的類瘋牛病蛋白折疊行為。
The malformed prion proteins can be deposited in the brain, thereby destroying brain tissue.
致病性的朊病毒蛋白質(zhì)在腦中沉積并損傷腦組織。
We have shown an initial proof of this principle by following the evolution of prion disease in mice.
我們藉由追蹤實(shí)驗(yàn)小鼠體內(nèi)普恩蛋白疾病的進(jìn)展,對(duì)這個(gè)理論有了初步的驗(yàn)證。
When these MRI findings are observed in an appropriate clinical context, the diagnosis of prion disease is very likely.
當(dāng)這些MRI表現(xiàn)是在一個(gè)適當(dāng)的觀察臨床方面,朊病毒疾病的診斷是非常可能的。
CJD is a progressive fatal neurodegenerative disorder caused by prion proteins accumulating within the neurons.
CJD是一種進(jìn)行性致命性神經(jīng)變性疾病,是由于朊病毒在神經(jīng)元內(nèi)堆積所致。
When he added an anti-prion drug to the mix, though, the virus production halted.
而混合了抗朊病毒藥物后,老病毒的生產(chǎn)就停止了。
Surgeon or Designee will notify the Operating Room of the brain biopsy of suspected prion disease.
外科醫(yī)生或操作者應(yīng)通知可疑朊毒體病人進(jìn)行腦組織活檢的手術(shù)室。
Several manufacturers have also addressed the concern over prion transmission.
一些制造商們還討論了關(guān)注朊病毒傳染。
Until that question is answered, the new era of the prion will remain confusing and frightening.
如果這一問(wèn)題得不到解答,朊病毒的新時(shí)期將仍然充滿困惑和恐懼。
Although the wastewater generated from the experiment was clear of prion protein presence, the biosolids were not.
雖然實(shí)驗(yàn)產(chǎn)生的廢水中沒(méi)有朊病毒出現(xiàn),但廢水處理產(chǎn)生的污泥卻并非如此。
Still, scientists say new forms of prion diseases have arisen lately, and there's concern that they could hop to humans.
盡管如此,科學(xué)家說(shuō)近來(lái)出現(xiàn)了一些新的朊病毒疾病,人們擔(dān)心這些疾病可能會(huì)傳播到人類身上。
Prion diseases can be controlled, if not eradicated.
如果說(shuō)普朊病難以徹底消除的話,那也是可以控制的。
More importantly, preliminary results suggest they are effective at extending the lives of prion-infected mice.
更重要的是,初步的實(shí)驗(yàn)結(jié)果提示這些分子能有效延長(zhǎng)朊病毒感染小鼠的壽命,
They discovered that amyloid beta binds to the prion proteins normally found on neurons.
研究人員發(fā)現(xiàn)與,淀粉樣蛋白與通常是在神經(jīng)元上發(fā)現(xiàn)的朊病毒蛋白結(jié)合在一起。
There is currently no treatment for prion diseases, which include CJD in humans and bovine spongiform encephalopathy (BSE) in cattle.
目前還沒(méi)有普粒子疾病的治療辦法,包括人類的克雅氏病(CJD)和牛腦海綿狀病(瘋牛病,BSE)。
The canine family is evidently immune to prion diseases, but felines can contract them.
目前已證實(shí)犬科動(dòng)物對(duì)普恩蛋白疾病免疫,但貓科動(dòng)物有可能感染。
Available for free and commercial use, and available in OpenType format.
Prion可以免費(fèi)使用并且進(jìn)行商用,可在Opentype中獲得。
has now abated. But other prion disorders are on the rise, and there is concern that new strains will infect humans.
但其他朊病毒疾病有上升的趨勢(shì),以及人們擔(dān)心新菌株,將感染人類。
By exhaustive enumeration, we get the prion-like behavior of protein folding.
通過(guò)窮舉計(jì)算,我們觀察到了這種折疊行為。
Prion protein is a normal constituent of brain tissue in all mammals.
朊蛋白是一種腦組織中所有的哺乳動(dòng)物的正常組成部分。
Central to the pathogenesis of all forms of prion disease is the prion protein.
中央的發(fā)病機(jī)制中的一切形式的朊病毒疾病的朊蛋白。
Can the "flipped" BSE priori induce the normal human prion to flip?
這種“變形的”BSE普里安能誘發(fā)正常人普里安發(fā)生改變嗎?。
But it's not yet known whether the variant protects against other prion diseases.
但是目前還不清楚這一變異是否對(duì)其他由朊病毒引起的疾病有效。
Conclusion Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely.
結(jié)論:朊蛋白106-126肽段能夠誘導(dǎo)分化后的PC12細(xì)胞凋亡,具有明確的毒性作用。
What route does the prion follow from the mouth to the brain?
朊蛋白通過(guò)什么途徑從嘴巴進(jìn)入大腦?
He escaped from prion yesterday.
昨天他從監(jiān)獄逃跑了。
Objective To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells.
目的:研究朊蛋白106-126肽段在細(xì)胞水平上的毒性作用。
We should transform the traditional medical thinking model to research the mystery of prion.
必須轉(zhuǎn)變固有的醫(yī)學(xué)思維模式來(lái)看待朊病毒之謎,并從哲學(xué)角度探討了朊病毒病的出現(xiàn)。
In fact, at first glance, lack of prions seemed like a good thing because it made mice immune to prion infection.
事實(shí)上,在初期,缺少這種蛋白看起來(lái)和正常情況一樣,因?yàn)?/c>它使老鼠免疫這種蛋白的缺失。
All rates listed above are subject to change without prion notice.
以上價(jià)格如有變動(dòng),恕不另行通知。